The upper reaches of the Nenana flow out of the Nenana Glacier and runs south then west into a wide glacial valley and the primary access for the upper Class II stretch is from the Denali Highway at mile 20. This is a geologically interesting area as the river runs into the trench of the Denali Fault Line, a major source of earthquakes and mountain building processes. Canoes and kayaks are well suited for this region and fishing is decent at the tributary confluences.
